I'm not the kind of person who believes one loss has to ruin somebody, so I don't see any reason why he can't be booked as a main eventer going forward, but that's not Vince's philosophy. He likes to squander build up.Is there any use for Strowman after that loss? Giants just don't sell in 2017, and he's not exactly Lesnar in that he can take losses and still come off like a beast.
Strowman can be the new Big Show, drifting between midcard and main event as needed. I doubt that's what they'll do, but there's no reason you can't. He's not Lesnar but big guys are always easy to re-build, people take them seriously if you book them seriously because they're big.