Edge had to retire because of injuries and it also put him out numerous times when he had lots of momentum. So he's easily up there.
Mr. Kennedy's main event push in the WWE was impacted by him getting injured right before it started and then he was released partly because of being so injury prone.
Batista missed two Wrestlemanias because of injuries so him too.
And you can count Austin too, I guess. But outside of the late 90s, he was not out due to injuries until they started nagging him in the end, forcing him to retire after WM19.
Can't forget Rey Mysterio either. Hasn't he had like 15 surgeries on his knees? He's away due to his knee problems every other year.
Mr. Kennedy's main event push in the WWE was impacted by him getting injured right before it started and then he was released partly because of being so injury prone.
Batista missed two Wrestlemanias because of injuries so him too.
And you can count Austin too, I guess. But outside of the late 90s, he was not out due to injuries until they started nagging him in the end, forcing him to retire after WM19.
Can't forget Rey Mysterio either. Hasn't he had like 15 surgeries on his knees? He's away due to his knee problems every other year.