I can imagine Dante being a big, burly man with huge muscles and a stubble. He'll look like a white-haired Conan The Barbarian. The game will be a hybrid between a Third Person Shooter with cover mechanics (for the gun segments) and a God of War combat system. The story will be dark, the color palette will be gray and brown, and there will be copious amounts of blood and gore. I can just imagine it now.
Actually, if they made it a spin-off designed for Western audiences, I wouldn't be too much against it. If it's part of the main series, it's problematic. I always shudder when I think about Squaresoft's western "Final Fantasy" made for the SNES.