I don't know if someone heard of that TF2/Penny Arcade/HR/Sam&Max crossover on the works, well, they finally released some info:
Poker Night at the Inventory
Prepare for a different kind of poker night in a very different kind of club. In Poker Night at the Inventory, you'll deal with Penny Arcade's clever, cunning Tycho, Team Fortress 2's hulking Heavy, Homestar Runner's self-proclaimed "awesome icon" Strong Bad and the hyperkinetic "rabbity-thing" from Sam & Max. These characters come together in ways some never thought possible, in a setting few would have predicted. You'll experience a new style of poker, particularly when hands don't go the way of the other fiery competitors at the table.
Sounds interesting but I never expected it could be a Poker game.